Description
| Catalogue Number | P846 | |||||||||||||||||||
| Description | Intermediate molecular weighted compound, constituted by a macrocyclic gadolinium chelate. Blood pharmacokinetic very comparable to that of Gd-DOTA or Gd-DTPA but limited extravasation within the capillary bed | |||||||||||||||||||
| Main Applications | Contrast-Enhanced MR angiography, tissue perfusion, angiogenesis imaging (DCE, MRI, Ktrans analysis, blood volume imaging, permeability measurement, treatment follow-up) | |||||||||||||||||||
| Molecular characteristics |
– Gd content: one Gd atom per molecule – Hydrodynamic size: diameter is 2-3 nm – Molecular weight: 3.5 kDa – Dose: due to high relaxivity of P846, the injected dose is lower than that of conventional contrast agent like Gd-DOTA Recommended dose: 50 μmol/kg = 2.5 μL/g Example: for a 30g body weight mouse, injection volume is 75 μL – Relaxivities (s-1.mM-1, 37°C, Human Albumin Serum 4%)
– In vitro quantification techniques: P846 is a Gd-based contrast agent. Gd can be dosed by ICP-AES or ICP-MS. Another way to quantify Gd chelates is by T1 or T2 relaxometry, with assumption of r1 or r2.
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| Characteristics of the vial | – Concentration: [Gd] = 20 mmol/L
– Volume: 450 μL (5 mice dose approx.) – Other animal species: please contact us
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| Storage | Need to be stored at 4°C in a closed vial away from light | |||||||||||||||||||
| Notes | For in vitro or animal use only | |||||||||||||||||||
| Selected publications | [1] Peldschuss et al., Invest Radiol, 2008 [2] Lemasson et al., Radiology 2010 [3] Casneuf et al., Radiation Research 2011 [4] Heilmann et al., CMMI 2009 [5] Unpublished Guerbet data [6] Loveless, MRM 2011 [7] Jacquier et al, MAGMA 2008 | |||||||||||||||||||
