Description
| Catalogue Number | P04000 | |
| Description | Targeted contrast agent for angiogenesis molecular imaging. P04000 targets ανβ3 integrin over-expressed on the neo-vessels.Nano-emulsion containing iron oxide particles, designed for T2*w MR sequences | |
| Main Applications | Evaluation of angiogenesis status, evaluation of anti-tumoral treatment follow up based on ανβ3-expression | |
| Molecular characteristics |
– Hydrodynamic size: diameter is 180 nm
– Fe content: ~106 Fe atoms per particle – Integrin targeting: 3 500 RGD per particles – Recommended dose: 200 μmolFe/kg = 2.5 μL/g Example: for a 30g body weight mouse, injection volume is 75 μL – Recommended imaging time: up to 1h post injection (unbound contrast agent cleared from the blood) – Contrast mechanism: susceptibility effect – Histology: Perl’s staining – In vitro quantification techniques: P04000 is a Fe-based contrast agent. Thus, it is necessary to take into account the endogenous iron content for quantification in biological media by ICP-AES or ICP-MS. Another way for USPIO quantification is relaxometry, which is poorly sensitive to endogenous iron content. |
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| Characteristics of the vial |
– Concentration: [Fe] = 4.47 mgFe/mL – [Fe] = 80 mmol/L (MFe=56 g/mol)
– Volume: 450 μL (5 mice dose approx.)
– Other animal species: contact us
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| Storage | Need to be stored at 4°C in a closed vial away from light | |
| Notes | For in vitro or animal use only | |
| Selected publications | ||
