Fluorescent Dyes for Bioconjugation

CheMatech entered an agreement with Bioacts for the distribution of its unique fluorescent technologies, offers Flamma series with full spectrum for labeling antibodies, proteins, peptides and other biomolecules. Biomolecules which are fluorescence labeled by Flamma® compounds can be applied to fluorescence microscope, in-vivo imaging, Immunofluorescence(IF), cell-based reporter assays, fluorescence in situ hybridization(FISH), cell tracking, receptor labeling, etc. and other analyses of cells and tissues which are fluorescence oriented.

Flamma Fluors series – Reactive fluorescent dyes

Flamma
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ApoFlamma PS series

ApoFlamma® PS series is for researchers and scientists who wish to decrease cost and increase efficiency in apoptosis detection. ApoFlamma® PS series is an apoptosis detection probe that binds to phosphatidylserine. Phosphatidylserine (PS) is a phospholipid component, which usually resides in the inner leaflet of the cellular membrane. When a cell is undergoing apoptosis, PS becomes exposed to the surface of the cell. We have found a unique peptide sequence that specifically recognizes PS on the cell surface. Coupled with BioActs’ superior Flamma® Fluor Fluorescent dyes, this peptide-dye complex effectively recognizes and binds to PS on cellular surfaces to accurately indicate apoptotic cells.

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ApoFlamma H series

The conventional way of apoptosis detection is by using Annexin V probes. However, it has been noted the in vivo performance of annexin V still needs improvements in the areas of background noise and specificity to apoptotic cells. Through phage-display method, an unique peptide sequence was recently found to have specific affinity to histone H1 on the surface of apoptotic cells and the nucleus of necrotic cells. Compared to annexin V. ApoPep-1 is much less bulky which helps rapid clearance from blood circulation and efficient tissue penetration, which makes it more ideal for in vivo experiments. ApoFlamma® H series is a novel probe composed of Apopep-1 peptide and BioActs’ superior Flamma® Fluor fluorescent dyes.

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