Description
| Catalogue Number | P792 | |||||||||||||||||||
| Description | Monogadolinated MRI blood-pool agent of 5 nm diameter. Pharmacokinetics and biodistribution profiles consistent with a rapid-clearance blood-pool agent (RCBPA): mainly excreted by glomerular filtration with limited diffusion across normal endothelium | |||||||||||||||||||
| Main Applications | DCE-MRI (Ktrans modeling, tumoral characterization / treatment follow up), high resolution contrast-enhanced MR angiography (MRA), myocardial perfusion, arthrography, myocardial perfusion and viability | |||||||||||||||||||
| Molecular characteristics |
– Hydrodynamic size: diameter is approximately 5 nm (compared to 1 nm for Gd-DOTA)
– Gd content: 1 atom per particle – Molecular weight: 6.5 kDa
– Recommended dose: 50 μmol/kg = 2.5 μL/g
Example: for a 30g body weight mouse, injection volume is 75 μL
– Relaxivities (s-1.mM-1, 37°C, 4% Human Albumin Serum)
|
|||||||||||||||||||
| Characteristics of the vial |
– Concentration: [Gd] = 20 mmol/L |
|||||||||||||||||||
| Storage | Need to be stored at 4°C in a closed vial and away from light | |||||||||||||||||||
| Notes | For in vitro or animal use only | |||||||||||||||||||
| Selected publications | [1] Ceelen W et al. Br J Cancer 2007 [2] Dewey et al.Investigative Radiology 2004 [3] Watrin Pinzano A et al. Biomed Mater Eng 2008 [4] Ruehm et al. Magnetic Resonance in Medicine 2002 [5] Dirksen MS et al. Eur Radiol 2003 [6] Herborn CU et al. Invest Rad | |||||||||||||||||||
